Direct and Transdentinal (Indirect) Antibacterial Activity of Commercially Available Dental Gel Formulations against Streptococcus mutans

Tüzüner, T. and Ulusoy, A.T. and Baygin, O. and Yahyaoglu, G. and Yalcin, I. and Buruk, K. and Nicholson, John W. (2013) Direct and Transdentinal (Indirect) Antibacterial Activity of Commercially Available Dental Gel Formulations against Streptococcus mutans. Medical Principles and Practice. ISSN 1011-7571 (In Press)

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Official URL: http://dx.doi.org/10.1159/000347234

Abstract

**Objective** To evaluate the direct and transdentinal (indirect) agar diffusion antibacterial activity of different commercially available antibacterial dental gel formulations against Streptococcus mutans. Materials and **Methods** The commercially available dental gel formulations were Corsodyl® (COG, 1% chlorhexidine), Cervitec® (CEG, 0.2% chlorhexidine + 0.2% sodium fluoride), Forever Bright® (FOB, aloe vera), Gengigel® (GEG, 0.2% hyaluronic acid), 35% phosphoric acid gel and distilled water (control). Direct agar diffusion was performed by isolating three wells from brain-heart infusion agar plates using sterile glass pipettes attached to a vacuum pump and adding 0.1 ml of the gels to each well. Transdentinal (indirect) agar diffusion was performed by applying gel to 0.2- and 0.5-mm-thick human dentin discs previously etched with phosphoric acid and rinsed with distilled water. Zones formed around the wells and the dentin discs were measured and analyzed using Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (p < 0.01). **Results** Direct agar diffusion tests showed significant differences among all gel formulations (p < 0.01) except for COG and CEG (p > 0.01). COG and CEG exhibited higher antibacterial effects compared to FOB and GEG (p < 0.01) in both direct and transdentinal (indirect) testing procedures. GEG did not show any antimicrobial activity in transdentinal (indirect) testing. **Conclusion** Commercially available dental gels inhibited S. mutans, which may indicate their potential as cavity disinfectants.

Item Type: Journal Article
Subjects: 600 Technology > 611 Human anatomy, cytology & histology
600 Technology > 615 Pharmacology & therapeutics
School/Department: School of Sport, Health and Applied Science
Depositing User: Jonathan Lucas
Date Deposited: 18 Apr 2013 15:44
Last Modified: 18 Apr 2013 15:44
URI: http://research.stmarys.ac.uk/id/eprint/377

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