Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes

BURDEN, RICHARD J. and POLLOCK, NOEL and WHYTE, GREGORY P. and RICHARDS, TOBY and MOORE, BRIAN and BUSBRIDGE, MARK and SRAI, SURJIT K. and OTTO, JAMES and PEDLAR, CHARLES R. (2015) Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes. Medicine & Science in Sports & Exercise, 47 (7). pp. 1399-1407. ISSN 0195-9131

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Burden 2015 MSSE 2014 Impact of Intravenous Iron-1.pdf - Accepted Version

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Official URL: https://doi.org/10.1249/MSS.0000000000000568

Abstract

Purpose: Iron-deficient athletes are often treated with long-term, low-dose iron therapy. Such treatments may be efficacious in correcting iron deficiency; however, the effect on acute and chronic iron metabolism and subsequent endurance capacity is less clear. Methods: Fifteen national and international standard runners were identified as iron deficient nonanemic (IDNA) and assigned to either an intravenous iron treatment group or placebo group. Participants completed three exercise tests to volitional exhaustion, as follows: before treatment, within 24 h, and 4 wk after treatment. Results: Serum ferritin, serum iron, and transferrin saturation were significantly improved in the iron group after intervention and compared with those in placebo (P < 0.05). Hepcidin levels were significantly greater before and after exercise after the iron injection (P < 0.05), and this was independent of changes in interleukin-6. There were no differences between groups in red cell indices, total hemoglobin mass, V˙O2max, submaximal blood lactate, running economy, RPE, or time to exhaustion (P > 0.05). Conclusions: A single 500-mg intravenous iron injection is effective for improving iron status for at least 4 wk, but this does not lead to improved aerobic capacity. This investigation suggests that iron availability supersedes inflammation in the regulation of hepcidin in IDNA endurance athletes after acute intravascular iron injection treatment.

Item Type: Journal Article
Additional Information: As accepted for publication. The published Version of Record is accessible from: https://doi.org/10.1249/MSS.0000000000000568
Subjects: 500 Natural sciences & mathematics > 571 Physiology & related subjects
700 The arts; fine & decorative arts; recreation > 796 Athletic & outdoor sports & games
School/Department: School of Sport, Health and Applied Science
Depositing User: Kevin Sanders
Date Deposited: 25 Aug 2017 05:20
Last Modified: 25 Aug 2017 05:20
URI: http://research.stmarys.ac.uk/id/eprint/1716

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